Monday, May 25, 2009

Reactive Oxygen Species, Isotope Effect, Essential Nutrients, and Enhanced LongevityReactive Oxygen Species, Isotope Effect, Essential Nutrients, and

A method is proposed that has the potential to lessen detrimental damages caused by reactive
oxygen species (ROS) to proteins, nucleic acids, lipids, and other components in living
cells. Typically, ROS oxidize substrates by a mechanism involving hydrogen abstraction in a
rate-limiting step. The sites within these (bio)molecules susceptible to oxidation by ROS can
thus be “protected” using heavier isotopes such as 2H (D, deuterium) and 13C (carbon-13). Ingestion
of isotopically reinforced building blocks such as amino acids, lipids and components
of nucleic acids and their subsequent incorporation into macromolecules would make these
more stable to ROS courtesy of an isotope effect. The implications may include enhanced
longevity and increased resistance to cancer and age-related diseases.
DOI: 10.1089/rej.2006.0506

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