Sunday, April 10, 2016

Anti-ageing Molecules Translation to Clinic And Conference


Aging is a major risk factor for a number of chronic diseases, including cancer, type II diabetes, atherosclerosis, hypertension, myocardial infarction, stroke, and neurodegenerative diseases. In animal models, treatments that extend lifespan often protect against these chronic diseases and there is a reason to believe that a similar approach might work in humans. Therefore, the geroscience concept, which aims to prolong the healthy state of the human body, is likely to become a key paradigm of biomedicine in developed countries in coming decades (Seals et al., 2015) .

Today, more than 200 substances belong to this group, each reported to slow aging and/or increase lifespan in a variety of organisms, including yeasts, nematodes, fruit flies, and rodents, according to the Geroprotectors.org database. Despite such an impressive rate of discovery, not a single geropro- tector has yet reached the pharmaceutical market as a recognized intervention targeting aging.

This is due following reasons

a) There is no unified mechanistic concept of aging, and primary triggers of aging are still poorly understood.

b) There is no comprehensive system of objective human aging biomarkers.

c) Aging is not recognized as a disease or a complex of syndromes

d) The scientific community has no consensus view on the concept of geroprotectors, on selection criteria for potential geroprotectors, or on the development of appropriate classification schemes, efficiency ratings, and approaches for predicting and modeling geroprotective properties.

This issue has been previously discussed in researchgate and other sites..

According to GeneAge Database....there are around 1825 genes whose knockdown, knockout or overexpression is known to result in an increase in life span.

In recent review article published by Dr. Alex Zhavoronkov discusses about the primary selection criteria for the geroprotectors..........................................................Click here for downloading the article

Most commonly used geroprotectors

Acarbose
Dephernyl
D-glucosamine
Dihydroergocristine methanesulfonate
Ellagic acid
Glutathione
Metformin
Vinpocetine

All these molecules are et

In addition the there is a conference on longevity in Russia............click here for registration



Recent studies shows that these molecules may be anticancer drugs but may also be useful in attaining longevity. People interested in longevity conference and to learn more about the recent advancement in cancer therapy can visit the above page.


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