Thursday, October 29, 2015

Important Breakthroughs In Cancer and Ageing

Personalised medicine with mTOR inhibitors and Telomerase modulators may serve as important breakthroughs in medicine. May be it can fetch more attention of organisations like Cancer Research UK, NCI and other funding agencies help in fighting Cancer and Ageing related problems.

mTOR is nutrition driven pathway. Dietary restrictions causes down regulation of mTORC1 activity.  Hence, targeting it with its inhibitor may help in providing anti-ageing and anti-cancer effect as shown in figure below.

It shows effect mTORC1 effect on longevity.  A cancer cell needs lot of energy because of its increase growing rate. Inhibiting mTORC1 with specific inhibitor helps in providing longevity.

Scientific paper mTOR and longevity can be accessed from here

According to Peto's paradox, chances of acquiring cancer is more in humans compared to large animals like elephants or whale even though these big sized animals have large number of big sized cells compared to humans.

Metabolic perspective of Peto's paradox and cancer  can be accessed from here

It's observed that small number of cells divide faster than big sized cells. As a result there are chances to acquire large number of genetic errors in rapidly dividing small cells. And these errors simply keeps on accumulating due to cell division. These accumulation of errors leads development of cancer. Moreover, with every cell division Telomere located at the end of DNA also keeps shortening. So basically with every cell division a piece of information is lost due to DNA damage. Telomerase enzyme helps in prevention of this loss and maintains the Telomere length. This in turn helps in maintaining the original length of DNA and prevents chromosomal shortening.

Details of this basic biology can be visualised in following Youtube video.
Basic function of telomerase.

Identification molecules which can increase synthesis of telomerase has been of prime importance.  These agents can also help in reversing ageing or may be useful for cancer prevention. Understanding of how telomerase works can be seen from a video of famous scientist Prof. Michio Kaku.


  1. Resume Builder is your perfect route that helps you with your resume. It helps you in every facet of your resume from your actual resume to the cover letter and more. See more best pharmacy residency

  2. The creator has so delightfully enchanted the thought of group by this brilliant blog.
    Life Settlements

  3. A Guide to Free Genealogical Resources has emerged as a widely recognized hobby among many human beings. Most people pick to adapt their studies through going backward thru time. Others choose to begin their genealogical studies by using way of documenting and connecting with loved ones/folks that are presently alive.

  4. By revealing pupils early on to various drugstore settings, we discover that pupils can have a useful progression of discovering, education, and aiding true sufferers. Roseman University College of Pharmacy enables to get any easier, more potent learning atmosphere than class understanding alone.

  5. It’s necessary that Internet casinos enable payouts only with the device used for replenishments. That’s why gamers ought to think about future withdrawals on the preliminary stage. The presence of working permission is proof of reliability. To get hold of a license, an Internet casino ought to meet certain requirements. It concerns certified software program, security measures, and other issues. The information about a license is often presented on the official web site of a gaming facility.

  6. Thank you for sharing this blog all about how to deal with cancer and aging. This is very helpful not only to those who experience this but to all people.